| Date | Opponent | Home
Away | Result | Final
Score | UK
Half | Opp
Half | Halftime
Deficit | Notes |
|---|
| 1/28/1910 | Central University | A | L | 17 - 87 | 3 | 51 | 48 | - |
| 2/12/2008 | Vanderbilt | A | L | 52 - 93 | 11 | 41 | 30 | - |
| 3/14/1950 | CCNY | N | L | 50 - 89 | 20 | 45 | 25 | NIT (at New York, NY) |
| 1/6/1925 | Wabash | A | L | 10 - 57 | 4 | 28 | 24 | - |
| 2/16/2013 | Tennessee | A | L | 58 - 88 | 26 | 50 | 24 | - |
| 2/4/2025 | Mississippi | A | L | 84 - 98 | 31 | 54 | 23 | - |
| 12/5/2025 | Gonzaga | N | L | 59 - 94 | 20 | 43 | 23 | (at Nashville, TN) |
| 2/10/1936 | Notre Dame | A | L | 20 - 41 | 7 | 29 | 22 | - |
| 2/17/1990 | Alabama | A | L | 58 - 83 | 27 | 49 | 22 | - |
| 1/7/2006 | Kansas | A | L | 46 - 73 | 19 | 41 | 22 | - |
| 12/12/2020 | Notre Dame | H | L | 63 - 64 | 26 | 48 | 22 | - |
| 12/18/1926 | Cincinnati | H | L | 10 - 48 | 7 | 28 | 21 | - |
| 1/12/1980 | Alabama | H | L | 64 - 78 | 20 | 41 | 21 | - |
| 2/8/1989 | Vanderbilt | A | L | 51 - 81 | 18 | 39 | 21 | - |
| 11/24/2010 | Connecticut | N | L | 67 - 84 | 29 | 50 | 21 | Maui Classic Invitational (at Lahaina, HI) |
| 3/8/2014 | Florida | A | L | 65 - 84 | 28 | 49 | 21 | - |
| 2/7/1910 | Cincinnati | A | L | 17 - 47 | 6 | 26 | 20 | - |
| 12/11/1972 | North Carolina | N | L | 70 - 78 | 26 | 46 | 20 | (at Louisville, KY) |
| 12/6/2008 | Miami | H | L | 67 - 73 | 26 | 46 | 20 | - |
| 2/6/1909 | Central University | A | L | 20 - 35 | 6 | 25 | 19 | - |
| 1/5/1937 | Notre Dame | N | L | 28 - 41 | 9 | 28 | 19 | (at Louisville, KY) |
| 1/14/1967 | Florida | A | L | 72 - 89 | 26 | 45 | 19 | - |
| 2/23/1974 | Alabama | H | L | 71 - 94 | 27 | 46 | 19 | - |
| 2/27/1982 | Louisiana State | A | L | 78 - 94 | 26 | 45 | 19 | - |
| 12/9/1989 | Kansas | A | L | 95 - 150 | 61 | 80 | 19 | - |
| 2/21/1990 | Tennessee | A | L | 100 - 102 | 39 | 58 | 19 | - |
| 3/22/2001 | Southern California | N | L | 76 - 80 | 24 | 43 | 19 | NCAA East Regional Semifinals (at Philadelphia, PA) |
| 3/29/2003 | Marquette | N | L | 69 - 83 | 26 | 45 | 19 | NCAA Midwest Regional Finals (at Minneapolis, MN) |
| 1/22/1927 | Georgia Tech | A | L | 16 - 48 | 2 | 20 | 18 | - |
| 2/25/2009 | South Carolina | A | L | 59 - 77 | 28 | 46 | 18 | - |
| 3/5/1910 | Central University | H | L | 13 - 31 | 4 | 21 | 17 | State Championship Game |
| 3/11/1910 | Central University | A | L | 9 - 51 | 7 | 24 | 17 | - |
| 12/27/1989 | North Carolina | N | L | 110 - 121 | 47 | 64 | 17 | (at Louisville, KY) |
| 1/13/1990 | Louisiana State | A | L | 81 - 94 | 33 | 50 | 17 | - |
| 11/6/2018 | Duke | N | L | 84 - 118 | 42 | 59 | 17 | Champions Classic (at Indianapolis, IN) |
| 11/18/2025 | Michigan State | N | L | 66 - 83 | 27 | 44 | 17 | Champions Classic (at New York, NY) |
| 1/25/1919 | Centre College | A | L | 30 - 38 | 9 | 25 | 16 | - |
| 1/7/1933 | Creighton | A | L | 22 - 34 | 8 | 24 | 16 | - |
| 1/14/1950 | Tennessee | A | L | 53 - 66 | 20 | 36 | 16 | - |
| 3/13/1964 | Ohio | N | L | 69 - 85 | 24 | 40 | 16 | NCAA Mideast Regional Semifinals (at Minneapolis, MN) |
| 2/11/1967 | Mississippi State | H | L | 72 - 77 OT | 27 | 43 | 16 | - |
| 12/31/1968 | Wisconsin | N | L | 65 - 69 | 26 | 42 | 16 | (at Chicago, IL) |
| 12/7/1974 | Indiana | A | L | 74 - 98 | 38 | 54 | 16 | - |
| 1/17/1984 | Florida | A | L | 57 - 69 | 18 | 34 | 16 | - |
| 2/15/1994 | Louisiana State | A | W | 99 - 95 | 32 | 48 | 16 | - |
| 12/18/2004 | Louisville | A | W | 60 - 58 | 16 | 32 | 16 | - |
| 12/10/2005 | Indiana | N | L | 53 - 79 | 19 | 35 | 16 | (at Indianapolis, IN) |
| 11/18/2008 | North Carolina | A | L | 58 - 77 | 25 | 41 | 16 | - |
| 11/20/2022 | Gonzaga | A | L | 72 - 88 | 25 | 41 | 16 | - |
| 12/7/2024 | Gonzaga | N | W | 90 - 89 OT | 34 | 50 | 16 | (at Seattle, WA) |
| 1/19/1909 | Cincinnati | A | L | 25 - 41 | 7 | 22 | 15 | - |
| 1/19/1928 | Maryland | A | L | 7 - 37 | 1 | 16 | 15 | - |
| 12/20/1957 | West Virginia | H | L | 70 - 77 | 32 | 47 | 15 | UKIT |
| 2/16/1985 | Mississippi State | A | L | 69 - 82 | 25 | 40 | 15 | - |
| 12/31/1988 | Louisville | A | L | 75 - 97 | 35 | 50 | 15 | - |
| 3/20/1994 | Marquette | N | L | 63 - 75 | 24 | 39 | 15 | NCAA Southeast Regional Second Round (at St. Petersburg, FL) |
| 12/4/2004 | North Carolina | A | L | 78 - 91 | 32 | 47 | 15 | - |
| 1/27/2018 | West Virginia | A | W | 83 - 76 | 33 | 48 | 15 | SEC/Big 12 Challenge |
| 3/3/2018 | Florida | A | L | 67 - 80 | 33 | 48 | 15 | - |
| 3/1/2025 | Auburn | H | L | 78 - 94 | 34 | 49 | 15 | - |
| 3/28/2025 | Tennessee | N | L | 65 - 78 | 28 | 43 | 15 | NCAA Midwest Regional Semifinals (at Indianapolis, IN) [Non-SEC game] |
