Minimum Number: 5 Records Kept Since: 1962
| # | Player | Class | Game | Opponent | Assists |
|---|---|---|---|---|---|
| 1 | De'Aaron Fox | Fr. | 11/11/2016 | Stephen F Austin | 12 |
| 2 | Kyle Macy | So. | 11/26/1977 | Southern Methodist | 10 |
| 2 | Sahvir Wheeler | Jr. | 11/9/2021 | Duke | 10 |
| 4 | Cason Wallace | Fr. | 11/7/2022 | Howard | 9 |
| 5 | Jamal Murray | Fr. | 11/13/2015 | Albany | 8 |
| 6 | Dirk Minniefield | Fr. | 11/17/1979 | Duke | 6 |
| 6 | Rex Chapman | Fr. | 11/29/1986 | Austin Peay | 6 |
| 6 | John Pelphrey | Fr. | 11/19/1988 | Duke | 6 |
| 6 | Ramel Bradley | Fr. | 11/20/2004 | Coppin State | 6 |
| 10 | Jared Prickett | Fr. | 12/2/1992 | Wright State | 5 |
| 10 | DeAndre Liggins | Fr. | 11/14/2008 | Virginia Military | 5 |
| 10 | John Wall | Fr. | 11/16/2009 | Miami (OH) | 5 |
| 10 | Andrew Harrison | Fr. | 11/8/2013 | UNC-Asheville | 5 |
| 10 | Tyler Herro | Fr. | 11/6/2018 | Duke | 5 |
| 10 | Tre Mitchell | Jr. | 11/6/2023 | New Mexico State | 5 |
| 10 | Lamont Butler | Jr. | 11/4/2024 | Wright State | 5 |
| 10 | Brandon Garrison | Jr. | 11/4/2024 | Wright State | 5 |
| 10 | Kerr Kriisa | Jr. | 11/4/2024 | Wright State | 5 |
